Photocatalytic synthesis of CF₃-containing β-amino alcohols via covalent metal-organic frameworks.

ABSTRACT: The construction of CF₃-containing β-amino alcohols represents a promising approach for drug discovery due to their enhanced metabolic stability and tunable pharmacological properties. However, the development of non-noble metal heterogeneous photocatalysts for the efficient one-step synthesis of trifluoromethyl (CF₃)-containing β-amino alcohol motifs under mild conditions poses significant challenges. In this work, we successfully synthesized two photoactive covalent metal-organic frameworks capable of photocatalysing the one-step conversion of allylamines into CF₃-containing β-amino alcohols via trifluoromethylation and photooxidation. Notably, the catalytic reaction can be performed under continuous-flow conditions, reducing the reaction time from 12 h t

SUBMITTER: Chen X 

PROVIDER: S-EPMC12839521 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature