Sunlight PDT leveraging NIR-II nanospray: painless, hemostatic, anti-inflammatory therapy towards diabetic wound infections.

ABSTRACT: Photodynamic therapy (PDT), which relies on the activation of photosensitizers by specific wavelengths of light to generate reactive oxygen species (ROS) for targeted pathogen or diseased tissue eradication, offers substantial promise for clinical wound management. However, its application in diabetic wound management remains constrained by suboptimal therapeutic efficacy, recurrent infections, treatment-associated pain, scar formation, and dependence on costly specialized equipment. Here, we present a sunlight-activated nanospray formulation comprising chitosan oligosaccharide-coated nanoparticles (SPS), engineered for the rapid and effective management of diabetic wounds in outdoor and resource-limited settings. SPS enables efficient ROS generation under ambient natural light, thereby re

SUBMITTER: Ding Q 

PROVIDER: S-EPMC12839536 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature