Bacteroidesfinegoldii and Parabacteroides goldsteinii Mediate Fucoidan-Induced Attenuation of Intestinal Inflammation in Mice Through Betaine- and Spermidine-Related Pathways.

ABSTRACT: Fucoidan improves host health by enriching beneficial taxa such as Bacteroides and Parabacteroides, yet the underlying mechanisms remain unclear. This study validated the association between these two genera and fucoidan-mediated mitigation of intestinal inflammation in mice. Subsequently, the effects of Parabacteroides goldsteinii and Bacteroides finegoldii were evaluated in colitis mice, and the contributions of microbiota-associated metabolites spermidine and betaine were investigated in vitro. Both strains reduced IL-6 (32-36%), TNF-α (30-37%), and IL-1β (40-45%) levels and increased levels of catalase (25-35%) and glutathione peroxidase (31-45%) in the colon. Mechanically, these strains suppressed activation of the NF-κB and MAPK pathways and preserved tigh

SUBMITTER: Qin T 

PROVIDER: S-EPMC12839593 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature