Patient Similarity Networks for Irritable Bowel Syndrome: Revisiting Brain Morphometry and Cognitive Features.

ABSTRACT: Background: Irritable Bowel Syndrome (IBS) is a heterogeneous gastrointestinal disorder characterized by complex brain-gut interactions. Patient Similarity Networks (PSNs) offer a novel approach for exploring this heterogeneity and identifying clinically relevant patient subgroups. Methods: We analyzed data from 78 participants (49 IBS patients and 29 healthy controls) with 36 brain morphometric measures (FreeSurfer v7.4.1) and 6 measures of cognitive functions (5 RBANS domain indices plus a Total Scale score). PSNs were constructed using multiple similarity measures (Euclidean, cosine, correlation-based) with Gaussian kernel transformation. We performed community detection (Louvain algorithm), centrality analyses, feature importance analysis, and correlations with symptom se

SUBMITTER: Lundervold A 

PROVIDER: S-EPMC12839715 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature