Emerging Cell-Based Therapies for Systemic Sclerosis: From Stem Cells to CAR-T Cells.

ABSTRACT: Systemic sclerosis (SSc) is a disease in which malfunctioning immune cells lead to the formation of autoantibodies that damage blood vessels and body tissues. Fibrosis then develops in the affected organs. Its complex pathogenesis involves multiple immune and stromal cell types, soluble mediators, and dysregulated tissue repair, resulting in heterogeneous clinical manifestations and poor prognosis. Current disease-modifying therapies provide only modest benefits, often slowing but rarely reversing disease progression, and are associated with considerable adverse effects. These limitations have spurred the development of cell-based therapeutic strategies aimed at restoring immune tolerance and promoting tissue repair. In this review, we summarize recent advances in hematopoietic stem cell t

SUBMITTER: Chasov V 

PROVIDER: S-EPMC12839790 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature