Biomarkers for Predicting Malignant Transformation of Premalignant Lesions of the Larynx: A Systematic Review.

ABSTRACT: Background/Objectives: Premalignant laryngeal lesions carry a variable risk of malignant transformation to squamous cell carcinoma. Identifying reliable biomarkers that predict malignant transformation could improve patient management and surveillance strategies. The objective of this work is to perform a systematic review of the literature on biomarkers that predict malignant transformation of premalignant laryngeal lesions. Methods: We conducted a systematic review following PRISMA 2020 guidelines. The PubMed, Scopus and Embase databases, and Google Scholar were searched for studies published between January 2011 and November 2025. Studies investigating biomarkers that predict malignant transformation of histopathologically confirmed premalignant laryngeal lesions were incl

SUBMITTER: Rodrigo JP 

PROVIDER: S-EPMC12840134 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature