Multi-Target Anticancer Activity of Structurally Diverse Schiff Bases: Insights into Cell-Cycle Arrest, DNA Damage, Metabolic Signaling, and Biomolecular Binding.

ABSTRACT: Schiff bases are widely studied for their biological activities, yet structure-activity relationships governing their anticancer potential remain insufficiently understood. In this work, eight structurally diverse imine derivatives (A-H) were evaluated for their cytotoxic, biochemical, and biomolecular interactions in human cancer cells. Their antiproliferative effects were assessed in HeLa, A549, and LS174T cell lines, with MRC-5 fibroblasts used as a non-malignant control. Cytotoxicity screening identified three compounds (A, B, and F) with the highest potency, prompting further mechanistic investigation. Cell cycle analysis revealed G1 arrest and accumulation of sub-G1 populations for all three derivatives, with compound B additionally increasin

SUBMITTER: Joksimovic N 

PROVIDER: S-EPMC12840311 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature