Photocontrol of Non-Adherent Cell Adhesion via Azobenzene-PEG-Lipid/Cyclodextrin Host-Guest Interactions.

ABSTRACT: Controlling cell attachment to substrates with spatiotemporal precision is a key technological foundation in fields such as tissue engineering, cell sorting, and cell-cell interaction analysis. Among existing approaches, azobenzene-based photocontrollable systems offer a promising strategy for the reversible regulation of cell adhesion. However, most conventional systems rely on the intrinsic adhesion capacity of adherent cells. Consequently, although the importance of non-adherent cell types has grown in biomedical research, their dynamic manipulation remains insufficiently explored. In this study, we developed a versatile system to control cell adhesion based on host-guest interactions between an azobenzene-lipid conjugate and a cyclodextrin-functionalized substrate. Using human chronic

SUBMITTER: Kawakami M 

PROVIDER: S-EPMC12840613 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature