Somatostatin-Expressing Neurons Regulate Sleep Deprivation and Recovery.

ABSTRACT: Background/Objectives We re-analyzed publicly available gene expression profiles from the male mouse cortex under conditions of sleep deprivation (SD) using tensor decomposition-based unsupervised feature extraction, originally proposed by one of the authors in 2017. Methods We focused on two distinct expression patterns: genes whose levels were altered in SD and failed to normalize during recovery sleep (RS), and genes that overshot normal levels during RS. This selection excluded the expected "altered in SD and recovered in RS" pattern, which was not significantly observed. These two gene sets showed substantial overlap but were still distinct from each other. Results The analysis revealed that the selected gene sets were enriched in various brain regions as evidence

SUBMITTER: Kobayashi K 

PROVIDER: S-EPMC12840664 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature