Porphyromonas gingivalis Vesicles Control Osteoclast-Macrophage Lineage Fate.

ABSTRACT: Porphyromonas gingivalis (Pg), a keystone pathogen of chronic periodontitis, releases outer membrane vesicles (OMVs) that act as nanoscale vehicles to disseminate virulence factors within periodontal tissues and systemically beyond the oral cavity. Although Pg-OMVs are increasingly recognized as critical mediators of host-pathogen interactions, their effects on the differentiation and function of monocyte-macrophage/osteoclast lineage cells remain unclear. Here, we examined the impact of Pg-OMVs on the differentiation of RAW264.7 monocyte/macrophage-like cells into osteoclasts (OC) and/or macrophages (MΦ) in the presence of receptor activator of nuclear factor-κB ligand (RANKL). OMVs were isolated from Pg W83 and applied to RANKL-primed RAW264.7 cells usi

SUBMITTER: Leon E 

PROVIDER: S-EPMC12840716 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature