Interdependent Regulation of Alternative Splicing by Serine/Arginine-Rich and Heterogeneous Nuclear Ribonucleoprotein Splicing Factors.

ABSTRACT:

Background

Alternative pre-mRNA splicing is a combinatorial process involving serine/arginine-rich (SR) and heterogeneous nuclear ribonucleoprotein (hnRNP) splicing factors. These proteins can silence or enhance splicing based on their expression levels and binding positions.

Objectives

To better understand the combinatorial and interdependent regulation between SR and hnRNP splicing factors during alternative splicing.

Methods

Computational analyses were performed using cell knockdown and binding datasets from available databases.

Results

Analyses of differential splicing data for 9 SR proteins and 21 hnRNP knockdowns revealed statistically significant interdependent regulation among several RNA-binding protein (RBP) combinations, albeit at different levels. N

SUBMITTER: Holmes ME 

PROVIDER: S-EPMC12840759 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature