Gut Microbiota-Derived Metabolite and Heart Failure with Reduced Ejection Fraction (HFrEF): Elevated Trimethylamine N-Oxide (TMAO) as a Potential Biomarker.

ABSTRACT: Gut-derived metabolites, particularly trimethylamine N-oxide (TMAO), have been implicated in the pathophysiology of heart failure (HF). This study investigated the associations between TMAO, cardiac function, and clinical parameters to evaluate TMAO's potential as a biomarker for heart failure with reduced ejection fraction (HFrEF). Forty HFrEF patients and forty-one matched healthy controls were recruited for serum TMAO quantification using enzyme-linked immunosorbent assay (ELISA). Associations were examined using Spearman correlation and regression models. TMAO levels were significantly elevated in HFrEF patients (3.64 µM [IQR 3.00-4.31]) compared with controls (1.22 µM [IQR 0.92-2.36]) (p < 0.05). Elevated TMAO correlated with impaired cardiac structural and functional parameter

SUBMITTER: Kuan SW 

PROVIDER: S-EPMC12840905 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature