Design and Characterization of Gold Nanorod Hyaluronic Acid Hydrogel Nanocomposites for NIR Photothermally Assisted Drug Delivery.

ABSTRACT: The combination of gold nanoparticles (AuNPs) with hydrogels has drawn significant interest in the design of smart materials as advanced platforms for biomedical applications. These systems endow light-responsiveness enabled by the AuNPs localized surface plasmon resonance (LSPR) phenomenon. In this study, we propose a nanocomposite hydrogel in which gold nanorods (AuNRs) are included in an agarose-carbomer-hyaluronic acid (AC-HA)-based hydrogel matrix to study the correlation between light irradiation, local temperature increase, and drug release for potential light-assisted drug delivery applications. The gel is obtained through a facile microwave-assisted polycondensation reaction, and its properties are investigated as a function of both the hyaluronic acid molecular weight and ratio.

SUBMITTER: Molinelli A 

PROVIDER: S-EPMC12840936 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature