CellMCD Effectively Discovers Drug Resistance and Sensitivity Genes for Acute Myeloid Leukemia.

ABSTRACT:

Background

Rapid advances in biotechnology provide researchers with the opportunity to integrate omics profiles (genomics, epigenomics, transcriptomics, proteomics, etc.) with multiple phenotypes or experimental conditions. In cancers such as acute myeloid leukemia (AML), where combination therapies are standard of care, identifying genetic drivers of drug resistance requires evaluating how genes are associated with multiple drug response phenotypes. Statistical analyses associating omics profiles with multiple phenotypes yield multiple significance values and rankings for each of many genes. There is a great need to consolidate these multiple rankings into a consensus ranking to prioritize specific genes for detailed follow-up wet-lab or clinical studies.

Methods/results

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SUBMITTER: Obodo D 

PROVIDER: S-EPMC12841039 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature