The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.

ABSTRACT: Human zinc finger Ran-binding protein 3 (ZRANB3) is crucial for DNA damage tolerance (DDT), as it prevents excessive damage, restores fork progression, and ultimately maintains genome stability. This unique and ancient architecture mainly exerts its function during replication fork reversal (RFR) and within the p53/Polι axis; thus, ZRANB3 is considered a tumour suppressor. However, possible additional roles in DNA synthesis and cell metabolism have been proposed. In tumour cells, ZRANB3 gene expression is deregulated, a condition that is frequently associated with poor survival and adverse clinical outcomes. ZRANB3 can be altered by functional mutations, gene copy number alterations, and a combination of the two. Although its mRNA levels typically correlate with p53 expressio

SUBMITTER: Pelucchi P 

PROVIDER: S-EPMC12841045 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature