Machine Learning Reveals Common Regulatory Mechanisms Mediated by Autophagy-Related Genes in the Development of Inflammatory Bowel Disease and Major Depressive Disorder.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is more common in patients with Inflammatory Bowel Disease (IBD) than in the general population, suggesting a shared but unclear pathogenesis. Autophagy, a conserved intracellular cleaning process, maintains cellular health by removing debris and recycling nutrients. Given the limited research on autophagy in this comorbidity, this study investigated the role of autophagy-related genes in both disorders.

Aim

This study aimed to identify shared autophagy-related mechanisms between IBD and MDD and to explore potential therapeutic strategies.

Methods

We identified differentially expressed autophagy-related genes (DE-ARGs) in diseased versus normal tissues. Shared DE-ARGs between IBD and MDD were designated Co-DEGs. We analyzed c

SUBMITTER: Wang G 

PROVIDER: S-EPMC12841238 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature