Construction of Phylogenetic Relationships Based on 8-mer Spectra Distribution Characteristics of Vertebrate Whole Genome Sequences.

ABSTRACT: Background/Objectives: With advances in sequencing technology, whole genome sequences have become a valuable resource for deciphering species evolution. However, efficiently extracting phylogenetic information from such data remains a major challenge. Traditional multiple sequence alignment methods are computationally intensive and perform poorly for distantly related species, while k-mer analysis offers a new direction for efficiently capturing genomic composition and evolutionary signatures. Methods: Feature extraction based on 8-mer spectra from 16 XYi subsets. Results: This study found that the distribution characteristics of whole genome sequences 8-mer spectra are closely related to species evolution. Building on this, we developed a dual-feature strategy for gen

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12841270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature