Impact of HSV-1 Infection on Alzheimer's Disease Neurodegeneration Markers: Insights from LUHMES 2D and 3D Neuronal Models.

ABSTRACT: Herpes simplex virus type 1 (HSV-1) has been proposed as an environmental risk factor for Alzheimer's disease (AD). Viral infection of neuronal cells can reproduce hallmark pathological features of AD, including intracellular beta-amyloid (Aβ) accumulation, tau hyperphosphorylation, and lysosomal dysfunction. However, the molecular mechanisms underlying these alterations remain unclear, partly due to limitations of existing experimental models. Here, we established both two-dimensional (2D) and three-dimensional (3D) LUHMES neuronal cultures-a human mesencephalic-derived neural cell line that differentiates rapidly into mature neurons-to investigate HSV-1-induced AD-associated markers. Our results demonstrate that HSV-1 infection induces key features of AD, including intracellular accumula

SUBMITTER: Martin-Rico M 

PROVIDER: S-EPMC12841366 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature