Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behcet's Disease in a Turkish Population.

ABSTRACT: Behçet's disease is a chronic, multisystem inflammatory disorder characterized by recurrent mucocutaneous and ocular manifestations, in which genetic factors, particularly cytokine gene polymorphisms, are thought to contribute to disease susceptibility. This study aimed to investigate the association of Interleukin-12B and Interleukin-23R gene polymorphisms and haplotype distributions with Behçet's disease in Denizli, a province of Turkey. A total of 88 patients with Behçet's disease and 133 healthy controls were genotyped for Interleukin-12B (rs3213119, rs3213120, rs3212227, rs3213113, rs2082412) and Interleukin-23R (rs1004819, rs7517847, rs7530511, rs10489629, rs10889677) polymorphisms using polymerase chain reaction-restriction fragment length polymorphism an

SUBMITTER: Arıkan S 

PROVIDER: S-EPMC12841561 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature