Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.

ABSTRACT: Melanocortin-2 receptor accessory protein 2 (MRAP2) is essential for the intricate regulation of energy balance. Although rare MRAP2 variants have been reported in obese individuals, their overall impact on human obesity risk remains uncertain because previous studies were small, heterogeneous, and often lacked systematic functional characterization. To address this gap, we conducted a comprehensive systematic review and cohort-level meta-analysis to quantify the association between rare coding variants in MRAP2 and obesity. We systematically searched five major databases (Embase, PubMed, Scopus, Google Scholar, and Web of Science) and identified five eligible publications comprising seven independent cohorts. In total, 27 rare coding MRAP2 variants were observed in 46

SUBMITTER: Ji RL 

PROVIDER: S-EPMC12841619 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature