Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.

ABSTRACT: Acromegaly is a rare endocrine disease characterized by multiple metabolic abnormalities and high cardiovascular risk. This cross-sectional study evaluated the lipidomic serum profile of 109 participants (59 acromegaly patients versus 50 healthy controls) via high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). The lipidomic profile that differentiated acromegaly from controls included sphingomyelins (SMs), glycerophospholipids, glycerolipids, ceramides, fatty acids, wax esters (WEs), carnitines, and sterol (ST) lipids. SM 34:0;O2 and phosphorylcholine best distinguished acromegaly patients from controls (VIP > 2.49). SM 34:0;O2 levels were significantly elevated in treatment-naïve versus uncontrolled patients (p < 0.0001). Furthermore, SM 34:0;O2 positi

SUBMITTER: Stanoiu-Pinzariu O 

PROVIDER: S-EPMC12841705 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature