Maternal Aspirin Treatment Improves Ischemic Stroke Outcome in Adult Male Offspring From Experimental Preeclamptic Dams.

ABSTRACT:

Background

Preeclampsia, a serious hypertensive disorder of pregnancy, is associated with increased long-term risk of cardiovascular disease in adult offspring, particularly stroke. Although low-dose aspirin (LDA) is used prophylactically to prevent preeclampsia, its impact on offspring is unclear. This study investigated the effect of maternal LDA treatment during experimental preeclampsia (ePE) on adult first-generation (F1) offspring, including stroke outcome.

Methods

ePE was induced in pregnant Sprague-Dawley rats via a high-cholesterol diet starting on gestational day 7 and treated with LDA (1.5 mg/kg) or vehicle. Offspring were weaned and fed standard chow until transient middle cerebral artery occlusion at 12 to 18 weeks (3-hour ischemia and 1-hour reperfusion). Fetal

SUBMITTER: Hunt RD 

PROVIDER: S-EPMC12841936 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature