Non-Coding RNA Profile in the Progression of Carotid Atherosclerosis: A Systematic Review.

ABSTRACT: Carotid atherosclerosis remains one of the primary etiological factors underlying ischemic stroke, contributing to adult neurological disability and mortality. In recent years, non-coding RNAs (ncRNAs) have emerged as key regulators of gene expression, actively modulating molecular pathways involved in atherogenesis. This systematic review, the first to be exclusively focused on carotid atherosclerosis, aimed at synthesizing current findings on the differential expression of ncRNAs throughout the natural history of the disease, thus providing the first comprehensive attempt to delineate a stage-specific ncRNA expression profile in carotid disease. A comprehensive literature search was conducted in PubMed and Scopus databases in January 2025, following PRISMA guidelines. Original studies in

SUBMITTER: Sardelli G 

PROVIDER: S-EPMC12842102 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature