Extracellular Vesicles (EVs) Derived from Senescent Endothelial Cells Promote Platelet Activation.

ABSTRACT: Thrombotic cardiovascular diseases are frequent side effects of cancer therapy with cytotoxic drugs such as Doxorubicin. Endothelial cell senescence is emerging as a critical mechanism underlying endothelial dysfunction in this context. Senescent cells, although unable to proliferate, secrete bioactive molecules that alter the tissue microenvironment, a feature known as the senescence-associated secretory phenotype (SASP). Besides soluble molecules, senescent cells also release extracellular vesicles (EVs). Previous studies indicate that senescent endothelial cells produce a secretome that promotes platelet activation; however, the contribution of EVs remains unclear. Here, we show that human microvascular endothelial cells (HMEC-1) exposed to Doxorubicin undergo senescence, display endoth

SUBMITTER: Venturini W 

PROVIDER: S-EPMC12842113 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature