Transcriptome Dynamics of BmN Cells During the Early Phase of Bombyx mori Nucleopolyhedrovirus Infection.

ABSTRACT: The silkworm, Bombyx mori, is an economically important insect severely impacted by Bombyx mori nucleopolyhedrovirus (BmNPV), a double-stranded DNA virus that causes substantial losses to the sericulture industry. To elucidate the mechanisms of BmNPV infection and replication, we performed transcriptome sequencing of BmN cells infected with a recombinant BmNPV at 12 and 24 h post infection (hpi). A total of 1136 differentially expressed genes (DEGs) were identified in the 12 hpi group, including 789 up-regulated and 347 down-regulated genes, while 5191 DEGs were detected at 24 hpi, including 2102 up-regulated and 3089 down-regulated genes. Functional annotation via GO and KEGG analyses highlighted the ECM-receptor interaction pathway as particularly significant. Furthermore,

SUBMITTER: Wang X 

PROVIDER: S-EPMC12842127 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature