SHIV.D Infection Alters Production and Protein Composition of Myeloid-Derived Extracellular Vesicles.

ABSTRACT: Although neurological disease is common in people with human immunodeficiency virus (HIV) (PWH), the contributing factors and underlying inflammatory mechanisms remain challenging to identify. Extracellular vesicles (EVs) constitute a relatively uncharacterized modality of intercellular communication and bioactive cargo transport in the setting of viral infection and pathogenesis. EVs carry inflammatory mediators to areas of the periphery during antiretroviral therapy (ART) suppression but are understudied in the brain. Using a biologically relevant simian-human immunodeficiency chimeric virus with a clade D HIV envelope (SHIV.D)-infected rhesus macaque (RM) model of HIV persistence in the central nervous system (CNS), we investigate circulating EV populations and the protein cargo of myel

SUBMITTER: Podgorski RM 

PROVIDER: S-EPMC12842161 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature