Dendritic Cell-Derived Extracellular Vesicles Mediate Inflammation in Egg Allergy Patients.

ABSTRACT: Atopic allergy is rising globally and placing a significant strain on healthcare systems, yet the understanding of the underpinning mechanisms of allergic sensitization remains incomplete. Extracellular vesicles (EVs) have recently emerged as important mediators of immune modulation, due to their diverse cargo, and therefore may play a mechanistic role in allergic sensitization development. Thus, this study investigated whether EVs released by activated dendritic cells (DCs) contribute to allergic sensitization of the common egg allergen, ovalbumin (OVA). DCs were generated from human monocytes cultured with GM-CSF and IL-4, then stimulated with LPS and/or OVA. EVs were subsequently isolated using size-exclusion chromatography and added to freshly isolated naive T cells at defined time poi

SUBMITTER: Tucis D 

PROVIDER: S-EPMC12842409 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature