Beyond the Usual Suspects: Unmasking Low-T2 Asthma in Children.

ABSTRACT:

Background

T2 low asthma in children is an emerging yet underexplored endotype that challenges traditional views of type 2 inflammation. Recent data suggest that it is more prevalent than previously thought and is defined by low type 2 biomarkers, non-allergic clinical profiles, and strong associations with modifiable comorbidities such as obesity, passive smoke exposure, and recurrent respiratory infections. This phenotype often shows a poor response to standard inhaled corticosteroid therapy and T2-targeted biologics, underscoring the urgent need for improved diagnostic and therapeutic approaches.

Methods

This narrative review conducted a literature search from PubMed and WoS databases (2020-2025), focusing on T2-low asthma defined by low blood eosinophils (<150-300/µL), F

SUBMITTER: Mrkic Kobal I 

PROVIDER: S-EPMC12842524 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature