Redefining the Collagen Composition of Human Fasciae: Emerging Collagen Types and Structural Heterogeneity.

ABSTRACT: Fascia has traditionally been described as a passive connective tissue mainly composed of collagen types I and III. Recent research, however, has revealed its structural and functional complexity, suggesting the possible presence of additional collagen types. This study aimed to quantify the presence and distribution of collagen types I, III, VI, and XII in human superficial and deep fasciae to improve understanding of fascial extracellular matrix composition. Superficial and deep fascia samples were collected from 19 adult patients (ages 20-83 years; thigh and lumbar area). Histology, Azan Mallory staining, hydroxyproline quantification, Western blotting, and immunohistochemistry were performed. The results indicated that deep fascia contained significantly more total collagen than superf

SUBMITTER: Fede C 

PROVIDER: S-EPMC12842560 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature