Microenvironment Modulates Tumorigenicity of Breast Cancer Cells Depending on Hormone Receptor Status.

ABSTRACT: Adipose tissue plays a crucial role in breast cancer (BC) progression by actively modulating the tumor microenvironment. We investigated how tumor proximity modifies adipose tissue by analyzing selected adipose-related and prognosis-associated markers in explants from BC patients and healthy donors. Explants were categorized by proximity to the tumor as adjacent (less than 2 cm), distant (over 2 cm), alongside normal explants (controls). FABP4 and vimentin expression was increased in proximity to the tumor, while caveolin-1, CD44, MMP9, and adiponectin showed minimal or no changes. Conditioned media (CM) from adjacent and normal explants were then assessed for their effects on tumorigenic traits in hormone-receptor-positive breast cancer (HR+ BC) and trip

SUBMITTER: Pagnotta P 

PROVIDER: S-EPMC12842586 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature