Interaction Between Frailty and Renal Function in Patients with Heart Failure.

ABSTRACT: Background. Frailty is highly prevalent among patients with heart failure (HF) and is associated with adverse clinical outcomes. Chronic kidney disease (CKD) frequently coexists with HF and may further increase risk. However, the clinical profile linking frailty and CKD remains insufficiently characterized. This study aimed to determine the prevalence and clinical correlates of frailty in outpatients with HF and to assess whether its prognostic significance varies across CKD severity. Methods. A prospective, observational cohort of HF outpatients was enrolled. Frailty was defined according to Fried's phenotype (≥3 criteria). Factors associated with frailty were identified using logistic regression. The primary endpoint was a composite of all-cause mortality or HF hospitalizat

SUBMITTER: Rodriguez-Eguren A 

PROVIDER: S-EPMC12842626 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature