Lycium barbarum polysaccharides enhance testicular spermatogenesis in d-galactose-induced aging rats via calcium signaling.

ABSTRACT:

Background

Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d-galactose-induced testicular dysfunction in reproductively senescent rats are not fully understood.

Materials and methods

A d-galactose-induced senescence model in male rats and a d-galactose-induced TM3 cell model were used to investigate the effects of LBP. The protective effect on testicular spermatogenic function was assessed by histological analysis and SA-β-gal staining. In addition, key calcium signaling pathway alterations involved in LBP were assessed using a multi-omics approach and validated by tissue. Single-cell sequencing data were used to further analyz

SUBMITTER: Ma W 

PROVIDER: S-EPMC12842857 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature