Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes.

ABSTRACT:

Background

Epidemiological studies have reported an association between advanced paternal age at conception and an increased risk of neurodevelopmental disorders in offspring, such as autism spectrum disorder. Evidence suggests that DNA methylation alterations in spermatozoa of older men may be transmitted to the feto-placental unit and associated with offspring brain development and behavioral differences later in childhood.

Objective

We aimed to assess the association of advanced paternal age with DNA methylation alterations in the human placenta and compare the results to previous findings in spermatozoa.

Methods

For this study, 64 placenta samples from the Design, Develop, and Discover (3D) prospective birth cohort study were categorized based on paternal age at c

SUBMITTER: Barnwell J 

PROVIDER: S-EPMC12842882 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature