Tailoring the Properties of Marine-Based Alginate Hydrogels: A Comparison of Enzymatic (HRP) and Visible-Light (SPS/Ruth)-Induced Gelation.

ABSTRACT: Alginate is a natural polysaccharide extracted from brown algae and is commonly used as a biomaterial scaffold in tissue engineering. In this study, we performed phenol functionalization of sodium alginate based on chemical modification methods using 1-ethyl-(3-dimethylaminopropyl)carbodiimide/N-hydroxybutanediimide/2-(N-morpholino) ethanesulfonic acid (EDC/NHS/MES) and tyramine. The presence of phenol groups was confirmed by spectrophotometry and Fourier Transform Infrared. We successfully prepared hydrogels using a horseradish peroxidase/hydrogen peroxide (HRP/H₂O₂) enzymatic system as well as an sodium persulfate (SPS)/ruthenium light-crosslinking system. Optimization identified 1 mM ruthenium and 4 mM SPS as the most effective photo crosslinking conditions. At the

SUBMITTER: Wang F 

PROVIDER: S-EPMC12842925 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature