Uncovering Sex and Gender Differences in Sarcoidosis: A Systematic Review of Current Evidence.

ABSTRACT: Introduction: Sarcoidosis is a systemic granulomatous disorder classified among interstitial lung diseases (ILDs). While the lungs and intrathoracic lymph nodes are most affected, the disease can involve multiple organs. The heterogeneity of clinical presentation arises from complex interactions between environmental exposures and immune responses in genetically susceptible individuals. Sex-dependent genetic variations are associated with differences in phenotype and organ localization. Gender-related factors also influence the impact of sarcoidosis on quality of life and health perception, contributing to variability in disease burden and outcomes. Aim of the study: to provide an overview of sex- and gender-related differences in sarcoidosis, focusing on pathophysiological a

SUBMITTER: Pianigiani T 

PROVIDER: S-EPMC12843133 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature