Comparison of Local Control and Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated with Induction Chemotherapy and Intensity-Modulated Radiotherapy: Conventional vs. Hyperfractionated Regimens.

ABSTRACT: Background and Objectives: T4 nasopharyngeal carcinoma (NPC) is a locally advanced disease with a high risk of local recurrence despite advances in radiotherapy techniques. Induction chemotherapy followed by intensity-modulated radiotherapy (IMRT) is a standard approach, but the optimal fractionation strategy remains uncertain. We conducted a retrospective study comparing survival and local control rates in T4 NPC patients treated with induction chemotherapy followed by IMRT using either conventional fractionation (CF) or hyperfractionation (HF). Methods: This study included 171 non-metastatic T4 NPC patients treated with induction chemotherapy and IMRT/arc therapy (volumetric-modulated arc therapy and TOMOTHERAPY) between 2003 and 2021. The patients were divided into two gro

SUBMITTER: Hsieh HY 

PROVIDER: S-EPMC12843390 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature