High-Intensity Interval Training Attenuates Inflammation in Cardiorenal Syndrome Induced by Renal Ischemia-Reperfusion Injury in Rats.

ABSTRACT: Acute kidney injury (AKI), a common complication of renal and cardiovascular procedures, induces systemic inflammation that can lead to secondary cardiac injury. This study examined whether prior high-intensity interval training (HIIT) could modulate biochemical and histological markers of cardiac injury following renal ischemia-reperfusion (I/R). Thirty male Sprague-Dawley rats were assigned to Sham, Renal I/R, and HIIT groups; one rat in the I/R group and two in the HIIT group did not survive. Serum analyses included creatinine, CK, troponin I, LDH, and inflammatory cytokines. Renal injury was assessed using tubular and glomerular injury scores, and cardiac injury was evaluated by myocardial injury scoring, TUNEL staining, and expression of caspase-3, TNF-α, and Bax. Renal I/R induced re

SUBMITTER: Tsao PC 

PROVIDER: S-EPMC12843421 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature