Low PAPP-A Levels and Growth in Twin Pregnancies.

ABSTRACT:

Background/objectives

It is well established in the modern literature that newborns delivered from multiple gestations are more predisposed to low birthweight in comparison to their singleton equivalents. In this study, we sought to explore the potential of first-trimester biochemical (PAPP-A and free β-hCG) and biophysical indices (uterine artery Doppler) to predict low birthweight in one or both twins.

Methods

This is a retrospective cohort analysis of 400 twin viable pregnancies presenting for routine first-trimester assessment in four fetal medicine centers between 2014 and 2025. The examination included the recording of maternal demographic characteristics and medical history, the assessment of markers of aneuploidy and the fetal anatomy, the measurement of mean arteria

SUBMITTER: Sapantzoglou I 

PROVIDER: S-EPMC12843441 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature