Systematic Review: Exploring Inter-Species Variability in Diabetes Mellitus for Translational Medicine.

ABSTRACT: Interspecies variability in diabetes mellitus (DM) represents a critical challenge for translational medicine, as metabolic pathways, pancreatic architecture, and therapeutic responses differ substantially across animal models. This systematic review, conducted according to PRISMA 2020 guidelines, synthesized evidence from 86 eligible studies published between 2001 and 2025. Comparative data from rodents, dogs, cats, pigs, non-human primates, and humans were analyzed to identify species-specific patterns in insulin secretion, insulin resistance (IR), β-cell dysfunction, microbiota-metabolism interactions, and susceptibility to diabetic complications. Results indicate that spontaneous diabetes in dogs closely mirrors human type 1 diabetes (T1DM), whereas feline obesity-associated diabetes r

SUBMITTER: Hritcu LD 

PROVIDER: S-EPMC12843455 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature