Trends in the Management of Bladder Cancer with Emphasis on Frailty: A Nationwide Analysis of More Than 49,000 Patients from a German Hospital Network.

ABSTRACT:

Background

Bladder cancer (BC) predominantly affects older patients, and their multidisciplinary treatment often includes surgical intervention. Frailty can influence treatment decisions and is associated with poorer outcomes. This study analyses trends in demographics, treatment patterns and frailty in a large, nationwide, real-world inpatient cohort in Germany.

Methods

This retrospective observational study included a total of 49,139 consecutive patients, who received inpatient care for BC at all HELIOS hospitals in Germany between 2016 and 2022. Frailty was assessed using the Hospital Frailty Risk Score (HFRS) and categorised as low (<5), intermediate (5-15), or high (>15). Trends in HFRS, treatment modalities, and demographic variables were analysed using regression mode

SUBMITTER: Klatte T 

PROVIDER: S-EPMC12843476 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature