Layer V Neocortical neurons from individuals With drug-resistant epilepsy show multiple synaptic alterations but lack somatic hyperexcitability.

ABSTRACT: Although neuronal hyperexcitability is the primary mechanism underlying seizure activity in epilepsy, little is known about how different neuronal mechanisms at different organizational levels contribute to network hyperexcitability in the human epileptic brain. In this study, we determined a series of cellular and synaptic properties of Layer V pyramidal neurons from neocortical tissue of patients with drug-resistant epilepsy that may contribute to the hyperexcitable state associated with epilepsy. Using the whole cell, patch-clamp technique, and extracellular recordings, we determined the passive and active electrophysiological properties of Layer V pyramidal neurons with regular spiking phenotypes from temporal, parietal, and frontal neocortices surgically resected from individuals with

SUBMITTER: Marquez LA 

PROVIDER: S-EPMC12843513 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature