Olfactory bulbectomy induces neurobiological alterations in the prefrontal cortex and hyperlocomotion in male rats.

ABSTRACT: Major depressive disorder (MDD) is a leading cause of disability and encompasses various subtypes, including agitated depression which is associated with psychomotor agitation and elevated suicide risk. Although the olfactory bulbectomy (OBX) model has been extensively utilized to study depression-related behaviors, most studies have focused on the hippocampus, leaving the role of the prefrontal cortex (PFC) less explored. In this study, we examined the behavioral responses to novelty in the open field test and examined glial and neuronal alterations in the PFC of OBX rats. Our findings revealed that OBX induced hyperlocomotion, consistent with agitated depression. At the cellular level, OBX selectively increased the number of glial fibrillary acidic protein (GFAP)-positive astrocytes in t

SUBMITTER: Bautista-Carro MA 

PROVIDER: S-EPMC12843528 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature