S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.

ABSTRACT:

Objectives

Antenatal corticosteroids (aCS) are an important measure improving the outcome of preterm infants. Their influence on late-onset sepsis (LOS) risk remains inconclusive. The alarmin S100A8/A9 protects from LOS by regulating innate immune responses. We examined whether aCS impact on postnatal S100A8/A9 serum-levels and consequently on LOS risk.

Study design

In a prospective birth-cohort study of 162 preterm infants born before 32 gestational weeks, we determined postnatal S100A8/A9 serum-levels in relation to the timing of aCS and LOS incidence.

Results

aCS administration within 7 days before birth decreased LOS incidence in infants born via primary C-section compared to infants not exposed to aCS (5/69 (7.2%) vs. 4/27 (14.8%)). This effect was linked to incr

SUBMITTER: Kessler G 

PROVIDER: S-EPMC12843532 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature