Taurine Facilitates the Formation of Hepatocellular Carcinoma via the Bile Acid Pathway.

ABSTRACT:

Backgrounds

While the conditionally essential amino acid taurine is known to confer hepatoprotection against injury through anti-inflammatory and antioxidant mechanisms, it remains unclear whether it plays an active role in the process of hepatocarcinogenesis. Emerging research portrays taurine as a double-edged sword in oncology, with its capacity to either inhibit or facilitate carcinogenesis being contingent upon the specific tumor microenvironment.

Objectives

Investigating the effect of taurine on hepatocellular carcinoma progression and its underlying mechanisms.

Methods

A hydrodynamic tail vein injection (HDT) model of primary hepatocellular carcinoma was established in mice to validate the effects of taurine and its downstream bile acid synthesis pathway on liv

SUBMITTER: Huang Q 

PROVIDER: S-EPMC12843671 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature