Triazole and Pyrazole Hybrids of Electrophilic Natural Products as Promising Anticancer Agents.

ABSTRACT: Naturally inspired electrophilic scaffolds, such as chalcone, curcumin, aurone, C-5-monocarbonyl-curcumin, and bis-(arylidene)piperidone, are considered privileged structures because of their ability to interact with a variety of biological macromolecules, including receptors and enzymes. They thus serve as versatile platforms for drug discovery efforts aimed at developing structurally related analogues endowed with improved bioactivity. Five-membered nitrogen-based heterocycles, such as triazole and pyrazole, have been widely used in medicinal chemistry both as templates and spacers for the design of bioactive compounds; they indeed provide the advantage of enhancing favourable interactions with the target, while also improving solubility and bioavailability, along with reducing toxicity.

SUBMITTER: Fermo AD 

PROVIDER: S-EPMC12843775 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature