Discrimination of Bipolar Disorder and Schizophrenia Patients Based on LC-HRMS Lipidomics.

ABSTRACT: Background/Objectives: Schizophrenia (SCH) and bipolar disorder (BD) share overlapping symptoms and genetic factors, making differential diagnosis challenging and often leading to misdiagnosis. This study aimed to identify potential lipid biomarkers of serum capable of distinguishing BD from SCH. Methods: Lipid profiles of serum from 30 SCH and 31 BD patients were analyzed in triplicates using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Chemometric analysis was applied, including class and gender identifiers. Orthogonal partial least squares (OPLS) models with 1000 cross-validations were used to validate feature subsets. Results: The chemometric analysis included the most relevant metabolites in the comparison between all samples of SCH and BD pa

SUBMITTER: Jankovic MR 

PROVIDER: S-EPMC12843932 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature