Optimization of Stryphnodendron adstringens (Barbatimao) Extraction: Chemical Evaluation, Cytotoxicity, Antioxidant and Anti-Inflammatory Activities.

ABSTRACT: Extracts from the stem bark of Stryphnodendron adstringens (barbatimão) exhibit relevant medicinal properties, such as anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities, which reinforce their potential for developing herbal medicines. The $550 billion plant bioactive market (by 2030) demands safer, green-chemistry-aligned extraction methods for responsible industrial scaling. In this study, dry extracts obtained from the stem bark of S. adstringens were obtained by ultrasound-assisted maceration in one- and two-step extraction systems. Parameters such as yield, solvent evaporation time, cost, acute toxicity, epigallocatechin gallate (EGCG) concentration, cell viability, antioxidant potential, and anti-inflammatory activity were evaluated. High-EGCG t

SUBMITTER: Oliveira CNP 

PROVIDER: S-EPMC12843935 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature