Unlocking the Secrets of Roman Chamomile (Anthemis nobilis L.) Essential Oil: Structural Elucidation and Acute Toxicity of New Esters.

ABSTRACT: To address gaps in the characterization of Roman chamomile (Anthemis nobilis L., Asteraceae)-an ethnobotanically and commercially important species-we profiled its essential oil (EO), focusing on esters that are incompletely characterized or unreported. Comprehensive GC-MS of two commercial EOs and their chromatographic fractions, combined with synthesis and co-injection of reference compounds, enabled the identification of 190 constituents. We uncovered a homologous series of angelates, tiglates, and senecioates by partial-ion-current (PIC) screening (m/z 55, 83, 100, 101), augmented by co-injection and NMR confirmation. Among these EO constituents, four esters, methallyl 3-methylbutanoate (6h), methallyl senecioate (3h), 3-methylpentyl 2-methylbutanoate

SUBMITTER: Radulovic NS 

PROVIDER: S-EPMC12843988 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature