Repeatable Perming via Thiol-Michael Click Reaction: Using Amide Derived from Maleic Acid and Cystine.

ABSTRACT: Conventional perming relies on oxidative agents that significantly damage hair. The thiol-Michael click perming strategy derived from linear aliphatic diols and diamines has been developed to avoid oxidative damage, but lacks repeatable perming capabilities. In this study, a novel thiol-Michael click perming molecule was proposed for repeatable perming while avoiding oxidative damage. N,N'-bis(maleoyl)-l-cystine (MA2-CySS) was synthesized and characterized through Raman spectroscopy and ¹H NMR with MTT assay demonstrated no cytotoxicity up to 1000 μg/mL. Click reactivity analysis revealed that the reaction reached a plateau after 30 min, with alkaline pH and elevated temperatures significantly enhancing reactivity. MA2-CySS perming achieved efficiency comparable to

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12844010 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature