Plasma Metabolome and Metabolite Toxicity Profiling of Moderate-Intensity Running in Human Females.

ABSTRACT: Background: Existing exercise metabolomics studies have predominantly focused on changes in the type and abundance of metabolites, while rarely addressing the toxicity risk of differential metabolites. Metabolic toxicity refers to the potential of endogenous or exogenous metabolites to induce oxidative stress, cell death, and other forms of biological damage when excessively accumulated and serves as a key driver of metabolic disorders. This study aims to characterize the toxicity risk of plasma differential metabolites before and after a single session of moderate-intensity running, so as to investigate the exercise-induced changes in metabolic toxicity. Methods: A single-group self-pretest-posttest control design was adopted in this study. Participants were recruited from W

SUBMITTER: Fei Q 

PROVIDER: S-EPMC12844069 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature